Reflux
- Home
- Reflux
- Barret's
- Zollinger-Ellison syndrome
- Nissen fundoplication
- True Life Story
- Reflux in the News
- Reflux and Cerebral Palsy
- Videos to watch
- Food Plan
- FAQ - Reflux
- Nil Heartburn
No More Heart Burn, Heart burn or GERD vanished with heart burn diets, informative reflux help and best preventative no acid heartburn meals, drinks and care. Controll acid reflux disease or erradicate it, your choice.
Zollinger-Ellison syndrome
Zollinger-Ellison syndrome is a disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often, the cause is a tumor (gastrinoma) of the duodenum or pancreas producing the hormone gastrin. Gastrin then causes an excessive production of acid which can lead to peptic ulcers (in almost 95% of patients)
Gastrin works on stomach parietal cells causing them to secrete more hydrogen ions into the stomach lumen. In addition, gastrin acts as a trophic factor for parietal cells, causing parietal cell hyperplasia. Thus, there is an increase in the number of acid secreting cells and each of these cells produces acid at a higher rate. The increase in acidity contributes to the development of peptic ulcers in the stomach and duodenum. High acid levels lead to multiple ulcers in the stomach and small bowel. Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea. The diagnosis is also suspected in patients without symptoms who have severe ulceration of the stomach and small bowel, especially if they fail to respond to treatment.
Gastrinomas may occur as single tumors or as multiple, small tumors. About one-half to two-thirds of single gastrinomas are malignant tumors that most commonly spread to the liver and lymph nodes near the pancreas and small bowel. Nearly 25 percent of patients with gastrinomas have multiple tumors as part of a condition called multiple endocrine neoplasia type I (MEN I). MEN I patients have tumors in their pituitary gland and parathyroid glands in addition to tumors of the pancreas.
Symptoms
- epigastric pain (stomachache)
- vomiting blood (hematemesis) (occasional)
- difficulty in eating
- diarrhea
- steatorrhea
Diagnosis
The diagnosis of Zollinger-Ellison syndrome is made by several laboratory tests and imaging studies.
Laboratory tests:
- secretin stimulation test, which measures gastrin levels in response to secretin
- fasting gastrin levels
- antral acidity
Therapy
Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as famotidine and ranitidine) are used to slow down acid secretion. If possible the tumours should be surgically removed, or treated with chemotherapy. Octreotide can be used to slow down acid secretion.